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Maturity-onset diabetes of the young ( MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes.
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In 1974, Tattersall and Fajans coined the term mature onset diabetes of the young (MODY). [1] MODY is the most common form of monogenic diabetes and exhibits autosomal dominant inheritance. Patients with this form of diabetes can sometimes be mistaken for having either type 1 diabetes (DM1) or type 2 diabetes mellitus (DM2).
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Maturity-Onset Diabetes of the Young (MODY) is the most common form of monogenic diabetes resulting from a single gene mutation. It is characterized by mild hyperglycemia, autosomal dominant inheritance, early onset of diabetes (<25 years), insulin resistance, and preservation of endogenous insulin secretion. Currently, 14 MODY subtypes have been identified, with differences in incidence.
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Maturity-onset diabetes of the young (MODY), the historic term for some forms of monogenic diabetes, is a collection of inherited disorders of non-autoimmune diabetes mellitus (antibody-negative) that present at a young age of onset. The prevalence is estimated to be 1/10 000 in adults and 1/23 000 in children, although the prevalence of MODY.
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Maturity-onset diabetes of the young (MODY) is an unusual form of diabetes with specific features that distinguish it from type 1 and type 2 diabetes. There are 14 known subtypes of MODY, and mutations in three genes ( HNF1A, HNF4A, GCK) account for about 95% of all MODY cases. Diagnosis usually occurs before the age of 25 years, although less.
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The study of asymptomatic diabetes in young people took a new direction in 1958 when I became aware of a 70-year-old male patient who was diagnosed with diabetes at the age of 41 years ( Supplementary Fig. 1, individual III-5). He was blind from diabetic retinopathy at the age of 61 years and had an amputation for peripheral vascular disease.
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